The Monash Bioinformatics Platform exists to create a hub for bioinformatics activities at Monash. We have a core group of bioinformaticians with broad expertise and are building a loosely linked community of bioinformaticians across all of Monash. We are always available to help with specialist advice on experimental design or analysis. We also collaborate with groups around Monash on specific research projects. We are strongly of the opinion that the best analysis is done when a bioinformatician works closely with a biologist to help each other understand the others field.
The Monash Bioinformatics Platform also runs training workshops to introduce basic bioinformatics. These workshops are a great way to get an introduction to a type of analysis, but often it is necessary to spend time working with one of our members to customize an analysis for your specific needs.
We can also help with computing or storage resources required for bioinformatics projects, and run a regular special interest group for anyone at Monash interested in the nitty-gritty of bioinformatics. Please sign-up for our mailing-list to stay informed.
Key Monash Researchers
Dr Traude Beilharz heads the RNA Systems Biology Laboratory.
We are interested in how both coding and non-coding RNA is expressed and regulated in cells, and how the fine-tuning of this expression, which differentiates health from disease, is maintained.
Next-gen sequencing provides a holistic, systems level view of the RNA expression profile in cells, and since disease often leaves signature fingerprints of deregulation on such profiles, NGS can be a powerful diagnostic for various disease states including for cancer. My lab uses custom RNA-seq technologies in a diverse set of model organism and cultured-cells to study RNA dynamics. Specifically, we are interested in the post-transcriptional regulation of RNA that determines when, where and how often, mRNA is translated to make proteins. Because we seek to understand how every RNA in our system is regulated, our experiments often have 100s of millions of data-points and thus require the input of computational biologists.
The Ramialison group is studying development and disease. They are a multidisciplinary team of computational and molecular biologists who specialise in genomics. They conduct their research using new genomic technology and the zebrafish as a model organism.
Despite the availability of genome sequences for many model organisms, our understanding of developmental gene regulatory networks (GRNs) is still relatively poor. The Ramialison laboratory focusses on increasing our knowledge of network understanding by generating quality datasets, integrating this information using computational modelling, performing cross-species comparisons and using a combination of bioinformatics tools and zebrafish as a model system.
A/Prof. Jose M. Polo leads the Reprogramming and Epigenetics Laboratory. The laboratory is interested in the transcriptional and epigenetic mechanisms that govern pluripotency and the reprogramming of somatic cells into induced pluripotent stem (iPS) cells.
Being able to specifically reprogram a mature cellular program into a pluripotent state and from there back into another particular cellular program provides a unique tool to dissect the molecular and cellular events that permit the conversion of one cell type to another. We use bioinformatics extensively in our lab to analyse the transcriptomic and epigenetic changes that occur as cells change type.